Paraoxonase: a multifaceted biomolecule

B Goswami, D Tayal, N Gupta, V Mallika - Clinica Chimica Acta, 2009 - Elsevier
BACKGROUND: Paraoxonase enzyme was first identified as a protective barrier against
organophosphorus poisoning. After painstaking research spanning the last three decades …

Antioxidant mechanisms in nonalcoholic fatty liver disease

W Liu, SS Baker, RD Baker, L Zhu - Current drug targets, 2015 - ingentaconnect.com
Nonalcoholic fatty liver disease (NAFLD) represents a broad spectrum of histological
abnormalities with clinical presentations ranging from hepatic steatosis to nonalcoholic …

Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment

G Baskol, H Atmaca, F Tanrıverdi… - Experimental and …, 2007 - thieme-connect.com
The present study was designed to investigate the relationship between the serum levels of
oxidant-antioxidant system (malondialdehyde (MDA) level, Paraoxonase (PON1) activity …

[HTML][HTML] Noninvasive diagnosis of NASH and liver fibrosis within the spectrum of NAFLD

N Alkhouri, AJ McCullough - Gastroenterology & hepatology, 2012 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in
the United States, affecting an estimated 70 million Americans. The histologic spectrum of …

Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis

G Baskol, M Baskol, D Kocer - Clinical Biochemistry, 2007 - Elsevier
OBJECTIVES:: Oxidative stress is an important pathophysiological mechanism in non-
alcoholic steatohepatitis (NASH). We aimed to evaluate serum xanthine oxidase (XO)(as a …

Advances in noninvasive biomarkers for nonalcoholic fatty liver disease

GE Gîlcă-Blanariu, DS Budur, DE Mitrică, E Gologan… - Metabolites, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) currently represents one of the most common liver
diseases worldwide. Early diagnosis and disease staging is crucial, since it is mainly …

Paraoxonase 1 and non-alcoholic fatty liver disease: a meta-analysis

K Kotani, J Watanabe, K Miura, A Gugliucci - Molecules, 2021 - mdpi.com
Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease
(NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not …

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

MV Milaciu, ȘC Vesa, IC Bocșan… - Journal of clinical …, 2019 - mdpi.com
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver
diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with …

OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease

N Alkhouri, M Berk, L Yerian, R Lopez… - Digestive diseases and …, 2014 - Springer
Abstract Background and Aim Oxidative stress is a core abnormality responsible for disease
progression in nonalcoholic fatty liver disease (NAFLD). By employing a highly sensitive …

Systematic review of performance of non‐invasive biomarkers in the evaluation of non‐alcoholic fatty liver disease

MH Miller, MAJ Ferguson, JF Dillon - Liver International, 2011 - Wiley Online Library
This systematic review evaluates the many studies carried out to discover and evaluate non‐
invasive markers of non‐alcoholic fatty liver disease (NAFLD). Many different strategies and …