The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

Many naturalistic behaviors are built from modular components that are expressed
sequentially. Although striatal circuits have been implicated in action selection and …

In the basal ganglia (BG), anatomically segregated and topographically organized
feedforward circuits are thought to modulate multiple behaviors in parallel. Although …

The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles
underlying their pathway-specific modulation of target regions are not well understood …

An influential striatal model postulates that neural activities in the striatal direct and indirect
pathways promote and inhibit movement, respectively. Normal behavior requires …

The acquisition and execution of motor skills are mediated by a distributed motor network,
spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog …

Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

The role of the striatum in motor control is commonly assumed to be mediated by the two
striatal efferent pathways characterized by striatal projection neurons (SPNs) expressing …