Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that
are specific to certain disorders or syndromes. The objective of this paper is to summarise …

Anxiety disorders constitute the largest group of mental disorders with a high individual and
societal burden. Neurobiological markers of treatment response bear potential to improve …

Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies
considerably between patients. The International SSRI Pharmacogenomics Consortium …

Personalized medicine (personalized psychiatry in a specific setting) is a new model
towards individualized care, in which knowledge from genomics and other omic pillars …

Introduction: Millions of people worldwide suffer from depression, but despite advances in
pharmacological therapies, many patients do not experience symptomatic remission or …

For over a decade, the European Group for the Study of Resistant Depression (GSRD) has
examined single nucleotide polymorphisms (SNP) and clinical parameters in regard to …

Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-
economic burden. Antidepressants of different classes are prescribed to treat MDD, but …

Progress in understanding the role of monoamine neurotransmission in pathophysiology of
neuropsychiatric disorders was made after the discovery of the mechanisms of action of …

Pharmacological therapy represents one of the essential approaches to treatment of Major
Depressive Disorder (MDD). However, currently available antidepressant medications show …

The pharmacogenetics of antidepressants has been not only a challenging but also
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …