Making better chimeric antigen receptors for adoptive T-cell therapy
Chimeric antigen receptors (CAR) are engineered fusion proteins constructed from antigen
recognition, signaling, and costimulatory domains that can be expressed in cytotoxic T cells …
recognition, signaling, and costimulatory domains that can be expressed in cytotoxic T cells …
Phylodynamics for cell biologists
BACKGROUND The birth, death, and diversification of individuals are events that drive
biological processes across all scales. This is true whether the individuals in question …
biological processes across all scales. This is true whether the individuals in question …
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
T Umezu, H Tadokoro, K Azuma… - Blood, The Journal …, 2014 - ashpublications.org
Exosomes are small endosome-derived vesicles containing a wide range of functional
proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the …
proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the …
[HTML][HTML] Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma
BACKGROUND. Multiple myeloma is usually fatal due to serial relapses that become
progressively refractory to therapy. CD19 is typically absent on the dominant multiple …
progressively refractory to therapy. CD19 is typically absent on the dominant multiple …
[HTML][HTML] European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma
M Engelhardt, E Terpos, M Kleber, F Gay, R Wäsch… - …, 2014 - ncbi.nlm.nih.gov
Multiple myeloma management has undergone profound changes in the past thanks to
advances in our understanding of the disease biology and improvements in treatment and …
advances in our understanding of the disease biology and improvements in treatment and …
Relapse-fated latent diagnosis subclones in acute B lineage leukemia are drug tolerant and possess distinct metabolic programs
Disease recurrence causes significant mortality in B-progenitor acute lymphoblastic
leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples shows …
leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples shows …
Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile
B Paiva, T Paino, JM Sayagues… - Blood, The Journal …, 2013 - ashpublications.org
Circulating myeloma tumor cells (CTCs) as defined by the presence of peripheral blood (PB)
clonal plasma cells (PCs) are a powerful prognostic marker in multiple myeloma (MM) …
clonal plasma cells (PCs) are a powerful prognostic marker in multiple myeloma (MM) …
Chimeric antigen receptor-modified T cell therapy in multiple myeloma: beyond B cell maturation antigen
M Timmers, G Roex, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Chimeric antigen receptor (CAR)-modified T cell therapy is a rapidly emerging
immunotherapeutic approach that is revolutionizing cancer treatment. The impressive …
immunotherapeutic approach that is revolutionizing cancer treatment. The impressive …
Differentiation stage of myeloma plasma cells: biological and clinical significance
B Paiva, N Puig, MT Cedena, BG de Jong, Y Ruiz… - Leukemia, 2017 - nature.com
The notion that plasma cells (PCs) are terminally differentiated has prevented intensive
research in multiple myeloma (MM) about their phenotypic plasticity and differentiation …
research in multiple myeloma (MM) about their phenotypic plasticity and differentiation …
IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors
M Jourdan, M Cren, N Robert, K Bolloré, T Fest… - Leukemia, 2014 - nature.com
The recent understanding of plasma cell (PC) biology has been obtained mainly from
murine models. The current concept is that plasmablasts home to the BM and further …
murine models. The current concept is that plasmablasts home to the BM and further …