High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

H Huang, Z Dong, X Ren, B Jia, G Li, S Zhou, X Zhao… - Nano Research, 2023 - Springer
With the continuous appearance and expansion of high-strength hydrogels in emerging
fields such as industry, medicine, and green development, the synthesis and application of …

Advancements in gelatin-based hydrogel systems for biomedical applications: A state-of-the-art review

S Mohanto, S Narayana, KP Merai, JA Kumar… - International Journal of …, 2023 - Elsevier
A gelatin-based hydrogel system is a stimulus-responsive, biocompatible, and
biodegradable polymeric system with solid-like rheology that entangles moisture in its …

[HTML][HTML] The immune microenvironment in cartilage injury and repair

M Li, H Yin, Z Yan, H Li, J Wu, Y Wang, F Wei, G Tian… - Acta Biomaterialia, 2022 - Elsevier
The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

[HTML][HTML] Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation

X Liu, X Wan, B Sui, Q Hu, Z Liu, T Ding, J Zhao… - Bioactive Materials, 2024 - Elsevier
The impaired differentiation ability of resident cells and disordered immune
microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we …

Toward a better regeneration through implant‐mediated immunomodulation: harnessing the immune responses

B Zhang, Y Su, J Zhou, Y Zheng, D Zhu - Advanced science, 2021 - Wiley Online Library
Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …

An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation for regulating chronic inflammation and impaired angiogenesis of …

Y Yuan, D Fan, S Shen, X Ma - Chemical Engineering Journal, 2022 - Elsevier
Abstract At present, approximately 19–34% of diabetic patients (nearly 450 million) may
have complications involving diabetic foot ulcers (DFUs). Wound healing of DFUs still faces …

[HTML][HTML] Advanced hydrogels for cartilage tissue engineering: recent progress and future directions

M Hafezi, S Nouri Khorasani, M Zare… - Polymers, 2021 - mdpi.com
Cartilage is a tension-and load-bearing tissue and has a limited capacity for intrinsic self-
healing. While microfracture and arthroplasty are the conventional methods for cartilage …

Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases

JR Nakkala, Z Li, W Ahmad, K Wang, C Gao - Acta Biomaterialia, 2021 - Elsevier
The degree of tissue injuries such as the level of scarring or organ dysfunction, and the
immune response against them primarily determine the outcome and speed of healing …