Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …

The use of microRNAs as clinical cancer biomarkers is hindered by the absence of accurate,
fast and inexpensive assays for their detection in biofluids. Here we report a one-step and …

The frequent outbreak of global infectious diseases has prompted the development of rapid
and effective diagnostic tools for the early screening of potential patients in point-of-care …

The acceptability and feasibility of large-scale testing with lateral flow tests (LFTs) for clinical
and public health purposes has been demonstrated during the COVID-19 pandemic. LFTs …

Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we
show that small circular DNA nanostructures which partially match guide RNA sequences …

The emergence of CRISPR-Cas systems has accelerated the development of gene editing
technologies, which are widely used in the life sciences. To improve the performance of …

Fast, inexpensive, and multiplexed detection of multiple nucleic acids is of great importance
to human health, yet it still represents a significant challenge. Herein, we propose a nucleic …

Nucleic acid detection powered by CRISPR technology provides a rapid, sensitive, and
deployable approach to molecular diagnostics. While exciting, there remain challenges …

CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers
associated with human diseases. This is achieved through the binding of guide RNAs to a …