Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory
impairment. Recent functional imaging studies suggest that memory function is subserved …

Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …

Abstract β-amyloid (Aβ) deposition is pathognomic for Alzheimer's disease (AD), but may
occur in normal elderly people without apparent cognitive effect. Episodic memory …

Memory function is likely subserved by multiple distributed neural networks, which are
disrupted by the pathophysiological process of Alzheimer's disease (AD). In this study, we …

Current treatment in late-life cognitive impairment and dementia is still limited, and there is
no cure for brain tissue degeneration or reversal of cognitive decline. Physical activity …

Synaptic loss is the major neurobiological substrate of cognitive dysfunction in Alzheimer's
disease (AD). Synaptic failure is an early event in the pathogenesis that is clearly detectable …

Cross-sectional functional magnetic resonance imaging studies using a memory task in
patients with mild cognitive impairment have produced discordant results, with some studies …

The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Mild cognitive impairment (MCI), a condition characterizing poor cognition, is associated
with aging and depicts early symptoms of severe cognitive impairment, known as …