Spray drying formulation of amorphous solid dispersions
A Singh, G Van den Mooter - Advanced drug delivery reviews, 2016 - Elsevier
Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …
Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca
AB Anane-Adjei, E Jacobs, SC Nash, S Askin… - International Journal of …, 2022 - Elsevier
The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …
much of the early drug development portfolio and poses a major challenge in …
An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused …
FDM 3D printing has been recently attracted increasing research efforts towards the
production of personalized solid oral formulations. However, commercially available FDM …
production of personalized solid oral formulations. However, commercially available FDM …
Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
[HTML][HTML] Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions
A Saberi, M Kouhjani, D Yari, A Jahani… - Journal of Drug Delivery …, 2023 - Elsevier
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
A critical review of spray-dried amorphous pharmaceuticals: synthesis, analysis and application
B Wang, F Liu, J **ang, Y He, Z Zhang, Z Cheng… - International Journal of …, 2021 - Elsevier
New drugs are frequently found with poor water-solubility in recent pharmaceutical projects,
which brings difficulties of bioavailability for the clinical development of new drugs. When …
which brings difficulties of bioavailability for the clinical development of new drugs. When …
Classification of solid dispersions: correlation to (i) stability and solubility (ii) preparation and characterization techniques
Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …
Qualitative and quantitative methods to determine miscibility in amorphous drug–polymer systems
Amorphous drug–polymer systems or amorphous solid dispersions are commonly used in
pharmaceutical industry to enhance the solubility of compounds with poor aqueous …
pharmaceutical industry to enhance the solubility of compounds with poor aqueous …
The need for restructuring the disordered science of amorphous drug formulations
The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …
towards finding strategies to improve the solubility. One of the attractive approaches to …
Spray drying ternary amorphous solid dispersions of ibuprofen–An investigation into critical formulation and processing parameters
A design of experiment (DoE) approach was used to investigate the critical formulation and
processing parameters in spray drying ternary amorphous solid dispersions (ASDs) of …
processing parameters in spray drying ternary amorphous solid dispersions (ASDs) of …