All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Aims Renal inflammation, leading to fibrosis and impaired function is a major contributor to
the development of hypertension. The NLRP3 inflammasome mediates inflammation in …

Both animal models and human observational and genetic studies have shown that immune
and inflammatory mechanisms play a key role in hypertension and its complications. We …