DNA damage checkpoint execution and the rules of its disengagement
CQX Yam, HH Lim, U Surana - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …
Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clam** enabled by multi-subunit conformational changes
Structural maintenance of chromosomes (SMC) complexes are essential for chromatin
organization and functions throughout the cell cycle. The cohesin and condensin SMCs fold …
organization and functions throughout the cell cycle. The cohesin and condensin SMCs fold …
Instant Inhibition and Subsequent Self-Adaptation of Chlorella sp. Toward Free Ammonia Shock in Wastewater: Physiological and Genetic Responses
Z Chen, S Qiu, M Li, D Zhou, S Ge - Environmental Science & …, 2022 - ACS Publications
Free ammonia (FA) has been recently demonstrated as the primary stress factor
suppressing microalgal activities in high-ammonium wastewater. However, its inhibition …
suppressing microalgal activities in high-ammonium wastewater. However, its inhibition …
The separation pin distinguishes the pro– and anti–recombinogenic functions of Saccharomyces cerevisiae Srs2
Srs2 is an Sf1a helicase that helps maintain genome stability in Saccharomyces cerevisiae
through its ability to regulate homologous recombination. Srs2 downregulates HR by …
through its ability to regulate homologous recombination. Srs2 downregulates HR by …
Rtt105 regulates RPA function by configurationally stapling the flexible domains
Abstract Replication Protein A (RPA) is a heterotrimeric complex that binds to single-
stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins to coordinate …
stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins to coordinate …
Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA
Human DNA helicase B (HELB) is a poorly characterized helicase suggested to play both
positive and negative regulatory roles in DNA replication and recombination. In this work, we …
positive and negative regulatory roles in DNA replication and recombination. In this work, we …
A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A
The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for
the DNA damage and replication stress response. Mec1–Ddc2 “senses” single-stranded …
the DNA damage and replication stress response. Mec1–Ddc2 “senses” single-stranded …
Mms22-Rtt107 axis attenuates the DNA damage checkpoint and the stability of the Rad9 checkpoint mediator
The DNA damage checkpoint is a highly conserved signaling pathway induced by genotoxin
exposure or endogenous genome stress. It alters many cellular processes such as arresting …
exposure or endogenous genome stress. It alters many cellular processes such as arresting …
Rad54 and Rdh54 prevent Srs2-mediated disruption of Rad51 presynaptic filaments
Srs2 is a superfamily 1 (SF1) helicase that participates in several pathways necessary for
the repair of damaged DNA. Srs2 regulates formation of early homologous recombination …
the repair of damaged DNA. Srs2 regulates formation of early homologous recombination …
Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases
G Baranowska, D Misiorna, W Białek, K Kramarz… - Plos one, 2024 - journals.plos.org
Homologous recombination is a key process that governs the stability of eukaryotic
genomes during DNA replication and repair. Multiple auxiliary factors regulate the choice of …
genomes during DNA replication and repair. Multiple auxiliary factors regulate the choice of …