Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

Genomic sequencing analyses of a variety of human cancers have revealed that massive
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …

Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …

p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …