Osteoarthritis is a disease that impacts millions around the world, leading to significant
financial and medical burden for patients and the healthcare system. However, no effective …

Abstract O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAcylation) is a distinctive
posttranslational protein modification involving the coordinated action of O‐GlcNAc …

Background Osteoarthritis is an age-related disease that currently faces a lack of
symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory …

The ability of cartilage to regenerate and repair is limited. N-acetyl-d-glucosamine (GlcNAc)
is a nutritional supplement commonly used to activate chondrocytes. To prolong the duration …

UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage
proteoglycans and simultaneously acts as a substrate for O-GlcNAcylation. Here, we show …

Abstract O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is
a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O …

The development of central nervous system (CNS) can form perceptual, memory, and
cognitive functions, while injuries to CNS often lead to severe neurological dysfunction and …

Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction,
and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close …

Cartilages are unique in the family of connective tissues in that they contain a high
concentration of the glycosaminoglycans, chondroitin sulfate and keratan sulfate attached to …

Glucosamine (GlcN) is a glycosaminoglycan (GAGs) constituent in connective tissues. It is
naturally produced by our body or consumed from diets. In the last decade, in vitro and in …