Digital detection of exosomes by interferometric imaging

GG Daaboul, P Gagni, L Benussi, P Bettotti, M Ciani… - Scientific reports, 2016 - nature.com
Exosomes, which are membranous nanovesicles, are actively released by cells and have
been attributed to roles in cell-cell communication, cancer metastasis, and early disease …

Protein microarray technology: how far off is routine diagnostics?

M Cretich, F Damin, M Chiari - Analyst, 2014 - pubs.rsc.org
The nature of protein microarray platforms is favorable for multiplexing, leading to the
development of tools for personalised medicine and highly precise diagnostics. However, to …

The role of surface chemistry in the efficacy of protein and dna microarrays for label-free detection: An overview

E Chiodi, AM Marn, MT Geib, MS Ünlü - Polymers, 2021 - mdpi.com
The importance of microarrays in diagnostics and medicine has drastically increased in the
last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically …

Development of a high-sensitivity immunoassay for amyloid-beta 1–42 using a silicon microarray platform

P Gagni, L Sola, M Cretich, M Chiari - Biosensors and Bioelectronics, 2013 - Elsevier
In this work, we present a highly sensitive immunoassay for the detection of the Alzheimer's
disease (AD) biomarker amyloid-beta 1–42 (Aβ42) based on a label/label-free microarray …

Single nanoparticle detection for multiplexed protein diagnostics with attomolar sensitivity in serum and unprocessed whole blood

MR Monroe, GG Daaboul, A Tuysuzoglu… - Analytical …, 2013 - ACS Publications
Although biomarkers exist for a range of disease diagnostics, a single low-cost platform
exhibiting the required sensitivity, a large dynamic-range and multiplexing capability, and …

A microwave matrix sensor for multipoint label-free Escherichia coli detection

I Piekarz, S Gorska, S Odrobina, M Drab… - Biosensors and …, 2020 - Elsevier
This paper presents a microwave sensor designed as a capacitive matrix for label-free
Escherichia coli detection. The mean value of capacitances' change in the capacitive matrix …

Loss of exosomes in progranulin-associated frontotemporal dementia

L Benussi, M Ciani, E Tonoli, M Morbin, L Palamara… - Neurobiology of …, 2016 - Elsevier
Many cells of the nervous system have been shown to release exosomes, a subclass of
secreted vesicles of endosomal origin capable of transferring biomolecules among cells: this …

Modulation of electroosmotic flow in capillary electrophoresis using functional polymer coatings

L Sola, M Chiari - Journal of Chromatography A, 2012 - Elsevier
Capillary electrophoresis (CE) is one of the most powerful techniques for the separation of
biomolecules. However, the separation efficiency of proteins in CE is often compromised by …

Enhancing antibody serodiagnosis using a controlled peptide coimmobilization strategy

L Sola, P Gagni, I D'Annessa, R Capelli… - ACS infectious …, 2018 - ACS Publications
Antigen immunoreactivity is often determined by surface regions defined by the 3D
juxtapositions of amino acids stretches that are not continuous in the linear sequence. As …

A broadband capacitive sensing method for label-free bacterial LPS detection

A Rydosz, E Brzozowska, S Górska, K Wincza… - Biosensors and …, 2016 - Elsevier
In this paper, the authors present a new type of highly sensitive label-free microwave sensor
in a form of interdigital capacitor coated with T4 bacteriophage gp37 adhesin. The adhesin …