[HTML][HTML] Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology
High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …
menopausal women as it has an insidious progression and is the deadliest gynaecological …
The endometriotic tumor microenvironment in ovarian cancer
Women with endometriosis are at increased risk of develo** ovarian cancer, specifically
ovarian endometrioid, low-grade serous, and clear-cell adenocarcinoma. An important …
ovarian endometrioid, low-grade serous, and clear-cell adenocarcinoma. An important …
[HTML][HTML] Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
In this study, we investigate mechanisms leading to inflammation and immunoreactivity in
ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to …
ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to …
Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant ovarian cancers
Amplification and overexpression of the MYC oncogene in tumor cells, including ovarian
cancer cells, correlates with poor responses to chemotherapy. As MYC is not directly …
cancer cells, correlates with poor responses to chemotherapy. As MYC is not directly …
ST6Gal-I–mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion
Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling.
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells
FH Abdalbari, E Martinez-Jaramillo, BN Forgie, E Tran… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …
Structure-based optimization of a novel class of aldehyde dehydrogenase 1A (ALDH1A) subfamily-selective inhibitors as potential adjuncts to ovarian cancer …
BC Huddle, E Grimley, CD Buchman… - Journal of medicinal …, 2018 - ACS Publications
Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer
stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer …
stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer …
Adipokine apelin/APJ pathway promotes peritoneal dissemination of ovarian cancer cells by regulating lipid metabolism
Adipose tissue, which can provide adipokines and nutrients to tumors, plays a key role in
promoting ovarian cancer metastatic lesions in peritoneal cavity. The adipokine apelin …
promoting ovarian cancer metastatic lesions in peritoneal cavity. The adipokine apelin …
Synthesis and Systematic Investigation of Lepidiline A and Its Gold (I), Silver (I), and Copper (I) Complexes Using In Vitro Cancer Models and Multipotent Stem Cells
S Tóth, MF Szlávik, R Mandel, F Fekecs, G Tusnády… - ACS …, 2024 - ACS Publications
The imidazole alkaloid lepidiline A from the root of Lepidium meyenii has a moderate to low
in vitro anticancer effect. Our aim was to extend cytotoxicity investigations against a panel of …
in vitro anticancer effect. Our aim was to extend cytotoxicity investigations against a panel of …
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer
ZC Koc, VE Sollars, N Bou Zgheib, GO Rankin… - Frontiers in …, 2023 - frontiersin.org
Introduction Ovarian cancer is one of the leading causes of death for women with cancer
worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian …
worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian …