In metazoans apoptosis is a major physiological process of cell elimination during
development and in tissue homeostasis and can be involved in pathological situations. In …

Apoptosis and primary necrosis are the two modes of cell death induced by a lethal injury.
The majority of structural and biochemical events occurring during cell death can be …

In the United States, more than 40% of cancer patients develop brain metastasis. The
median survival for untreated patients is 1 to 2 months, which may be extended to 6 months …

Previous investigations have shown that 2-hydroxyethyl methacrylate (HEMA) causes
reactive oxygen species (ROS) production, which in turn affects cell survival and cell death …

Phenol contamination of soil and water has raised concerns among people living near
phenol-producing factories and hazardous waste sites containing the chemical. Phenol …

Brucellae are gram-negative intracellular pathogens that survive and multiply within host
phagocytic cells. Smooth organisms present O-polysaccharides (OPS) on their surface. The …

The potential toxicity of metal ions in tissues surrounding metal–metal hip replacements is a
cause for concern. Previous studies conducted in our laboratory demonstrated that Co2+ …

Photodynamic therapy (PDT) represents an emerging strategy to treat various malignancies,
including colorectal cancer (CC), the third most common cancer type. This work presents an …

Group A streptococci (GAS) produce several secreted products that are thought to enhance
pathogenicity by facilitating spread of the organisms through host tissues. Two such …

The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …