Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
The metabolic roots of senescence: mechanisms and opportunities for intervention
CD Wiley, J Campisi - Nature Metabolism, 2021 - nature.com
Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …
changes. Among these changes is the release of numerous biologically active molecules …
Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
Skin aging, cellular senescence and natural polyphenols
E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …
impacting its morphology and function. Senescent cells have been found to accumulate with …
Cellular senescence: defining a path forward
Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
The dynamic nature of senescence in cancer
Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …
development, wound healing, age-related decline in organ functions and cancer. Here, we …
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …
human cancers. p53 functions during cancer progression have been linked to a variety of …
The mitochondrial basis of aging
A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …
correlated with the development of a wide range of age-related diseases. Here, we review …
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation
and DNA damage response,. Perturbations of these processes are hallmarks of cancer and …
and DNA damage response,. Perturbations of these processes are hallmarks of cancer and …
Lipid metabolism in cancer
Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides,
phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular …
phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular …