Neutrophil extracellular traps in immunity and disease

V Papayannopoulos - Nature Reviews Immunology, 2018 - nature.com
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights

Y Döring, P Libby, O Soehnlein - Circulation research, 2020 - ahajournals.org
Neutrophil extracellular traps (NETs) have recently emerged as a newly recognized
contributor to venous and arterial thrombosis. These strands of DNA extruded by activated or …

An emerging role for neutrophil extracellular traps in noninfectious disease

SK Jorch, P Kubes - Nature medicine, 2017 - nature.com
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils
to help catch and kill bacteria. However, increasing evidence suggests that this process …

Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review

KH Lee, A Kronbichler, DDY Park, YM Park, H Moon… - Autoimmunity …, 2017 - Elsevier
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …

NETosis: how vital is it?

BG Yipp, P Kubes - Blood, The Journal of the American Society …, 2013 - ashpublications.org
In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various …

Recognition and control of neutrophil extracellular trap formation by MICL

M Malamud, L Whitehead, A McIntosh, F Colella… - Nature, 2024 - nature.com
Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular
traps (NETs), which are web-like structures composed of DNA and neutrophil-derived …

The role of neutrophil extracellular traps in rheumatic diseases

F Apel, A Zychlinsky, EF Kenny - Nature Reviews Rheumatology, 2018 - nature.com
Rheumatic diseases are a collection of disorders defined by the presence of inflammation
and destruction of joints and internal organs. A common feature of these diseases is the …

Neutrophil extracellular traps—the dark side of neutrophils

OE Sørensen, N Borregaard - The Journal of clinical investigation, 2016 - jci.org
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of
decondensed DNA in complex with histones and granule proteins, which were expelled …

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

K Martinod, M Demers, TA Fuchs, SL Wong… - Proceedings of the …, 2013 - pnas.org
Deep vein thrombosis and pulmonary embolism are major health problems associated with
high mortality. Recently, DNA-based neutrophil extracellular traps (NETs) resulting from the …

Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease

LJ O'Neil, MJ Kaplan - Trends in molecular medicine, 2019 - cell.com
Rheumatoid arthritis (RA), a common autoimmune disease, is characterized by a highly
coordinated inflammatory response that involves innate and adaptive immunity. One of the …