The environment and susceptibility to schizophrenia
AS Brown - Progress in neurobiology, 2011 - Elsevier
In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …
and synthesized. Accumulating evidence from recent studies suggests that environmental …
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility
CB Klune, B **, LA DeNardo - Elife, 2021 - elifesciences.org
The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …
play key roles in memory, cognition, decision making, social behaviors, and mood …
[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
NJ Brandon, A Sawa - Nature Reviews Neuroscience, 2011 - nature.com
Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …
disorders has blown away the diagnostic boundaries that are defined by currently used …
Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a “central hub” in schizophrenia pathophysiology?
P Steullet, JH Cabungcal, A Monin, D Dwir… - Schizophrenia …, 2016 - Elsevier
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …
Neurodevelopment, GABA system dysfunction, and schizophrenia
MJ Schmidt, K Mirnics - Neuropsychopharmacology, 2015 - nature.com
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …
Bleuler began documenting their findings. However, large clinical research efforts in recent …
To poly (I: C) or not to poly (I: C): advancing preclinical schizophrenia research through the use of prenatal immune activation models
The neurodevelopmental hypothesis of schizophrenia has been highly influential in sha**
our current thinking about modeling the disease in animals. Based on the findings provided …
our current thinking about modeling the disease in animals. Based on the findings provided …
Evidence for a dysregulated immune system in the etiology of psychiatric disorders
SM Gibney, HA Drexhage - Journal of Neuroimmune Pharmacology, 2013 - Springer
There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …
in both health and disease. In recent years, the role of an altered immune system in the …
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
BACKGROUND: Gene-environment interactions (GEI) are involved in the pathogenesis of
mental diseases. We evaluated interaction between mutant human disrupted-in …
mental diseases. We evaluated interaction between mutant human disrupted-in …