Transcriptomic profiling became a standard approach to quantify a cell state, which led to
the accumulation of huge amount of public gene expression datasets. However, both reuse …

Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

Background Diabetic nephropathy (DN) is a major microvascular complication of diabetes
and has become the leading cause of end-stage renal disease worldwide. A considerable …

Glaucoma is a leading cause of permanent blindness, affecting 80 million people worldwide.
Recent studies have emphasized the importance of neuroinflammation in the early stages of …

Introduction: Increasing evidences have shown that hypoxia and the immune
microenvironment play vital roles in the development of osteosarcoma. However, reliable …

Parkinson's disease (PD) is the second-most common neurodegenerative disease, affecting
10 million people worldwide. Neuroinflammation is one of the major pathologic processes in …

Dysferlin is a multi‐functional protein that regulates membrane resealing, calcium
homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in …

Background Clear cell renal cell carcinoma (ccRCC) is a widespread urogenital neoplasm.
However, the therapeutic efficacy of these methods is unsatisfactory. In-depth screening of …

The crosstalk between cancer and stromal cells plays a critical role in tumor progression.
Syntenin is a small scaffold protein involved in the regulation of intercellular communication …