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HLA/KIR restraint of HIV: surviving the fittest
AA Bashirova, R Thomas… - Annual review of …, 2011 - annualreviews.org
Multiple epidemiological studies have demonstrated associations between the human
leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more …
leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more …
Harnessing CD8+ T Cells Under HIV Antiretroviral Therapy
Antiretroviral therapy (ART) has transformed HIV from a fatal disease to a chronic condition.
In recent years there has been considerable interest in strategies to enable HIV-infected …
In recent years there has been considerable interest in strategies to enable HIV-infected …
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
MF Chevalier, B Jülg, A Pyo, M Flanders… - Journal of …, 2011 - journals.asm.org
Functional defects in cytotoxic CD8+ T cell responses arise in chronic human viral infections,
but the mechanisms involved are not well understood. In mice, CD4 cell-mediated …
but the mechanisms involved are not well understood. In mice, CD4 cell-mediated …
Definition of the viral targets of protective HIV-1-specific T cell responses
Background The efficacy of the CTL component of a future HIV-1 vaccine will depend on the
induction of responses with the most potent antiviral activity and broad HLA class I …
induction of responses with the most potent antiviral activity and broad HLA class I …
Heterodimeric proteins
G Moore, M Bernett, R Rashid, J Desjarlais - US Patent 10,858,417, 2020 - Google Patents
US10858417B2 - Heterodimeric proteins - Google Patents US10858417B2 - Heterodimeric
proteins - Google Patents Heterodimeric proteins Download PDF Info Publication number …
proteins - Google Patents Heterodimeric proteins Download PDF Info Publication number …
A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis
N Varadarajan, B Julg, YJ Yamanaka, H Chen… - The Journal of clinical …, 2011 - jci.org
CD8+ T cells are a key component of the adaptive immune response to viral infection. An
inadequate CD8+ T cell response is thought to be partly responsible for the persistent …
inadequate CD8+ T cell response is thought to be partly responsible for the persistent …
Optimized anti-CD3 variable regions
G Moore, M Bernett, R Rashid, J Desjarlais - US Patent 10,968,276, 2021 - Google Patents
C07K16/2809—Immunoglobulins [IGs], eg monoclonal or polyclonal antibodies against
material from animals or humans against receptors, cell surface antigens or cell surface …
material from animals or humans against receptors, cell surface antigens or cell surface …
EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive …
Suppression of HIV replication by antiretroviral therapy (ART) or host immunity can prevent
AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV …
AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV …
A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
SD Allard, B De Keersmaecker, AL de Goede… - Clinical …, 2012 - Elsevier
In a phase I/IIa clinical trial, 17 HIV-1 infected patients, stable on cART, received 4
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …
Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection: Learning in vivo dynamics using ex vivo data
While most individuals suffer progressive disease following HIV infection, a small fraction
spontaneously controls the infection. Although CD8 T-cells have been implicated in this …
spontaneously controls the infection. Although CD8 T-cells have been implicated in this …