Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
Diet, gut microbiome and epigenetics: emerging links with inflammatory bowel diseases and prospects for management and prevention
K Aleksandrova, B Romero-Mosquera, V Hernandez - Nutrients, 2017 - mdpi.com
Inflammatory bowel diseases (IBD) represent a growing public health concern due to
increasing incidence worldwide. The current notion on the pathogenesis of IBD is that …
increasing incidence worldwide. The current notion on the pathogenesis of IBD is that …
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
A Taber, E Christensen, P Lamy, I Nordentoft… - Nature …, 2020 - nature.com
Overtreatment with cisplatin-based chemotherapy is a major issue in the management of
muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for …
muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …
traits are becoming increasingly common. A series of papers reporting age-related changes …
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
Epigenetic alterations may provide important insights into gene-environment interaction in
inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation …
inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation …
Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
Purpose There is a critical need for population-based prospective cohort studies because
they follow individuals before the onset of disease, allowing for studies that can identify …
they follow individuals before the onset of disease, allowing for studies that can identify …
Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …
associated with a broad range of disease traits, including cancer, asthma, metabolic …
[HTML][HTML] DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy
DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into
epigenetic aging signatures to estimate donor age. It has been demonstrated that the …
epigenetic aging signatures to estimate donor age. It has been demonstrated that the …
[HTML][HTML] The role of diet in the prevention and treatment of Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBD)–Crohn's disease (CD) and ulcerative colitis (UC)–are
chronic conditions characterised by relapsing inflammation of the gastrointestinal tract. They …
chronic conditions characterised by relapsing inflammation of the gastrointestinal tract. They …