Modeling HIV persistence, the latent reservoir, and viral blips
HIV-1 eradication from infected individuals has not been achieved with the prolonged use of
highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting …
highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting …
Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
Patients in whom virologic suppression is achieved with highly active antiretroviral therapy
(HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV …
(HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV …
Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy
Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1
patients to below the detection limit of conventional clinical assays, a low level of viremia …
patients to below the detection limit of conventional clinical assays, a low level of viremia …
Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
Viral replication and latently infected cellular reservoirs persist in HIV-infected patients
achieving undetectable plasma virus levels with potent antiretroviral therapy. We exploited a …
achieving undetectable plasma virus levels with potent antiretroviral therapy. We exploited a …
Adaptation in the env Gene of HIV-1 and Evolutionary Theories of Disease Progression
S Williamson - Molecular biology and evolution, 2003 - academic.oup.com
The exact mechanisms by which HIV overwhelms the immune system remain poorly
understood. Among the several explanations of HIV disease progression, most include …
understood. Among the several explanations of HIV disease progression, most include …
Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
Most HIV-infected patients when treated with combination antiretroviral therapy achieve viral
loads that are below the current limit of detection of standard assays after a few months …
loads that are below the current limit of detection of standard assays after a few months …
Viral and latent reservoir persistence in HIV-1–infected patients on therapy
H Kim, AS Perelson - PLoS computational biology, 2006 - journals.plos.org
Despite many years of potent antiretroviral therapy, latently infected cells and low levels of
plasma virus have been found to persist in HIV-infected patients. The factors influencing this …
plasma virus have been found to persist in HIV-infected patients. The factors influencing this …
A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients
JM Conway, D Coombs - PLoS computational biology, 2011 - journals.plos.org
Motivated by viral persistence in HIV+ patients on long-term anti-retroviral treatment (ART),
we present a stochastic model of HIV viral dynamics in the blood stream. We consider the …
we present a stochastic model of HIV viral dynamics in the blood stream. We consider the …
Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers
Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads.
Suspension of therapy is followed by rebound of viral loads to high, pre-therapy levels …
Suspension of therapy is followed by rebound of viral loads to high, pre-therapy levels …
Pharmaceutical approaches to eradication of persistent HIV infection
MC Bowman, NM Archin, DM Margolis - Expert reviews in molecular …, 2009 - cambridge.org
Highly active antiretroviral therapy (HAART) has markedly decreased morbidity and mortality
in human immunodeficiency virus type 1 (HIV-1)-infected individuals in the developed world …
in human immunodeficiency virus type 1 (HIV-1)-infected individuals in the developed world …