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Rational design of allosteric modulators: Challenges and successes
Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles
Residue interaction networks (RINs) are used to represent residue contacts in protein
structures. Thanks to the advances in network theory, RINs have been proved effective as an …
structures. Thanks to the advances in network theory, RINs have been proved effective as an …
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals
Covering: up to the beginning of 2023 Many animals release volatile or semi-volatile
terpenes as semiochemicals in intra-and inter-specific interactions. Terpenes are important …
terpenes as semiochemicals in intra-and inter-specific interactions. Terpenes are important …
Impact of protein conformational diversity on AlphaFold predictions
Motivation After the outstanding breakthrough of AlphaFold in predicting protein 3D models,
new questions appeared and remain unanswered. The ensemble nature of proteins, for …
new questions appeared and remain unanswered. The ensemble nature of proteins, for …
MobiDB: intrinsically disordered proteins in 2021
The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …
intrinsically disordered proteins. Here, we report recent developments implemented in …
Organic cathode for aqueous Zn-ion batteries: taming a unique phase evolution toward stable electrochemical cycling
Aqueous zinc ion batteries are highly attractive for large-scale storage applications because
of their inherent safety, low cost, and durability. Yet, their advancement is hindered by a …
of their inherent safety, low cost, and durability. Yet, their advancement is hindered by a …
RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures
Residue interaction networks (RINs) are a valuable approach for representing contacts in
protein structures. RINs have been widely used in various research areas, including the …
protein structures. RINs have been widely used in various research areas, including the …
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization
J Su, G Wu, Y Ye, J Zhang, L Zeng, X Huang, Y Zheng… - Oncogene, 2021 - nature.com
Methylcytosine (m5C) is a posttranscriptional RNA modification participating in many critical
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species
Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus
(SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic …
(SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic …
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins
The MobiDB (URL: mobidb. bio. unipd. it) database of protein disorder and mobility
annotations has been significantly updated and upgraded since its last major renewal in …
annotations has been significantly updated and upgraded since its last major renewal in …