Rational design of allosteric modulators: Challenges and successes

A Chatzigoulas, Z Cournia - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles

D Clementel, A Del Conte, AM Monzon… - Nucleic acids …, 2022 - academic.oup.com
Residue interaction networks (RINs) are used to represent residue contacts in protein
structures. Thanks to the advances in network theory, RINs have been proved effective as an …

Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals

D Tholl, Z Rebholz, AV Morozov, PE O'Maille - Natural product reports, 2023 - pubs.rsc.org
Covering: up to the beginning of 2023 Many animals release volatile or semi-volatile
terpenes as semiochemicals in intra-and inter-specific interactions. Terpenes are important …

Impact of protein conformational diversity on AlphaFold predictions

T Saldaño, N Escobedo, J Marchetti, DJ Zea… - …, 2022 - academic.oup.com
Motivation After the outstanding breakthrough of AlphaFold in predicting protein 3D models,
new questions appeared and remain unanswered. The ensemble nature of proteins, for …

MobiDB: intrinsically disordered proteins in 2021

D Piovesan, M Necci, N Escobedo… - Nucleic acids …, 2021 - academic.oup.com
The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …

Organic cathode for aqueous Zn-ion batteries: taming a unique phase evolution toward stable electrochemical cycling

D Kundu, P Oberholzer, C Glaros, A Bouzid… - Chemistry of …, 2018 - ACS Publications
Aqueous zinc ion batteries are highly attractive for large-scale storage applications because
of their inherent safety, low cost, and durability. Yet, their advancement is hindered by a …

RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures

A Del Conte, GF Camagni, D Clementel… - Nucleic Acids …, 2024 - academic.oup.com
Residue interaction networks (RINs) are a valuable approach for representing contacts in
protein structures. RINs have been widely used in various research areas, including the …

NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

J Su, G Wu, Y Ye, J Zhang, L Zeng, X Huang, Y Zheng… - Oncogene, 2021 - nature.com
Methylcytosine (m5C) is a posttranscriptional RNA modification participating in many critical
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …

ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

H Yan, H Jiao, Q Liu, Z Zhang, Q **ong… - Nature ecology & …, 2021 - nature.com
Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus
(SARS-CoV) and the causal agent of the coronavirus disease 2019 (COVID-19) pandemic …

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins

D Piovesan, F Tabaro, L Paladin, M Necci… - Nucleic acids …, 2018 - academic.oup.com
The MobiDB (URL: mobidb. bio. unipd. it) database of protein disorder and mobility
annotations has been significantly updated and upgraded since its last major renewal in …