G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Chemokines are small chemotactic molecules that play key roles in physiological and
pathological conditions. Upon signaling via their specific receptors, chemokines regulate …

G protein-coupled receptors (GPCRs) represent the largest and most physiologically
important integral membrane protein family, and these receptors respond to a wide variety of …

G protein-coupled receptors (GPCRs) play a central role in cellular signaling and are linked
to many diseases. Accordingly, computational methods to explore potential allosteric sites …

Ever since the first biologically active chemokines were discovered in the late 1980s, these
messenger proteins and their receptors have been the target for a plethora of drug discovery …

Abstract Development of specific therapies that target and accelerate diabetic wound repair
is an urgent need to alleviate pain and suffering and the huge socioeconomic burden of this …

Chemokine receptors typically have multiple ligands. Consequently, treatment with a
blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here …

Biomolecular recognition such as binding of small molecules, nucleic acids, peptides and
proteins to their target receptors plays key roles in cellular function and has been targeted …

Acetate, an agonist for the free fatty acid receptor 2 (FFA2R/GPR43), triggers an increase in
the cytosolic concentration of free Ca2+ in neutrophils without any assembly of the …