Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in
bacterial infections. One of the most studied is probably xenophagy, the selective capture …

Research in recent years has focused significantly on the role of selective macroautophagy
in targeting intracellular pathogens for lysosomal degradation, a process termed xenophagy …

At the current rate of climate change, it is unlikely that multicellular organisms will be able to
adapt to changing environmental conditions through genetic recombination and natural …

Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to
treat and manage bacterial infection. The development and FDA approval of novel …

Intracellular bacterial pathogens have developed versatile strategies to generate niches
inside the eukaryotic cells that allow them to survive and proliferate. Making a home inside …

Abstract Background Non-Hodgkin's lymphoma (NHL) is a malignant disease of lymphoid
tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP …

Autophagy is an evolutionary conserved catabolic process devoted to the removal of
unnecessary and harmful cellular components. In its general form, autophagy governs …

Increasing use of engineered nanomaterials (ENMs) means increased human exposures.
Potential adverse effects include those on the immune system, ranging from direct toxicity to …

Francisella tularensis is one of the most virulent pathogenic bacteria causing the acute
human respiratory disease tularemia. While the mechanisms underlying F. tularensis …

Francisella tularensis is a zoonotic pathogen and the causative agent of tularemia. F.
tularensis replicates to high levels within the cytosol of macrophages and other host cells …