Industrial biocatalysis is an economically attractive option for the production of valuable
chemicals. Our repertoire of cheap building blocks and commodity target molecules is vastly …

Nascent polypeptides emerging from the ribosome are assisted by a pool of molecular
chaperones and targeting factors, which enable them to efficiently partition as cytosolic …

Synthetic biology has emerged as a multidisciplinary field that provides new tools and
approaches to address longstanding problems in biology. It integrates knowledge from …

Enzyme spatial organization is an evolved mechanism for facilitating multi‐step biocatalysis
and can play an important role in the regulation of promiscuous enzymes. The latter function …

The most common mechanism by which proteins aggregate consists in the assembly of
short hydrophobic primary sequence segments into extended β-structured agglomerates. A …

Amyloid deposits are associated with an increasing number of human disorders, including
Alzheimer's and Parkinson's diseases. Recent studies provide compelling evidence for the …

In nature, enzymes that catalyze sequential reactions are often assembled as clusters or
complexes. The formation of multienzyme complexes, or metabolons, brings the enzyme …

An emerging paradigm in the field of in vivo protein biophysics is that nascent-protein
behavior is a type of nonequilibrium phenomenon, where translation-elongation kinetics can …

Engineered proteins with enhanced or altered functionality, generated for example by
mutation or domain fusion, are at the core of nearly all synthetic biology endeavors in the …

The method of surface display allows the fusion of passenger proteins to a carrier protein
displayed on the outside of bioparticles such as spores. Here, we used spores of Bacillus …