Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Interplay between lipid metabolism, lipid droplets, and DNA virus infections

MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

C Dumesnil, L Vanharanta, X Prasanna… - Nature …, 2023 - nature.com
Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be
stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral …

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

YA Klug, JC Deme, RA Corey, MF Renne… - Nature …, 2021 - nature.com
Lipid droplets (LDs) are universal lipid storage organelles with a core of neutral lipids, such
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …

Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome

S Rogers, L Gui, A Kovalenko, V Zoni… - Journal of Cell …, 2022 - rupress.org
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

V Zoni, R Khaddaj, I Lukmantara… - Proceedings of the …, 2021 - National Acad Sciences
Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …

[HTML][HTML] Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters

MF Renne, RA Corey, JV Ferreira, PJ Stansfeld… - Journal of Cell …, 2022 - rupress.org
Lipid droplets (LDs) are essential for cellular lipid homeostasis by storing diverse neutral
lipids (NLs), such as triacylglycerol (TAG), steryl esters (SE), and retinyl esters (RE). A …

Lipid droplets control mitogenic lipid mediator production in human cancer cells

EJ Jovičić, AP Janež, TO Eichmann, Š Koren… - Molecular …, 2023 - Elsevier
Abstract Objectives Polyunsaturated fatty acids (PUFAs) are structural components of
membrane phospholipids and precursors of oxygenated lipid mediators with diverse …

Production, biosynthesis, and commercial applications of fatty acids from oleaginous fungi

XY Zhang, B Li, BC Huang, FB Wang, YQ Zhang… - Frontiers in …, 2022 - frontiersin.org
Oleaginous fungi (including fungus-like protists) are attractive in lipid production due to their
short growth cycle, large biomass and high yield of lipids. Some typical oleaginous fungi …