Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

The niche is a conserved regulator of stem cell quiescence and function. During ageing,
stem cell function declines. To what extent and by what means age-related changes within …

Niches are local tissue microenvironments that maintain and regulate stem cells. Long-
predicted from mammalian studies, these structures have recently been characterized within …

Stem cells self-renew but also give rise to daughter cells that are committed to lineage-
specific differentiation. To achieve this remarkable task, they can undergo an intrinsically …

The aging of tissue-specific stem cell and progenitor cell compartments is believed to be
central to the decline of tissue and organ integrity and function in the elderly. Here, we …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …

Mammalian aging is associated with reduced tissue regeneration, increased degenerative
disease, and cancer. Because stem cells regenerate many adult tissues and contribute to …

Metazoans employ cytoprotective and regenerative strategies to maintain tissue
homeostasis. Understanding the coordination of these strategies is critical to develo** …

Perivascular multipotent cells, pericytes, contribute to the generation and repair of various
tissues in response to injury. They are heterogeneous in their morphology, distribution …