Nanodiscs in membrane biochemistry and biophysics

IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

The styrene–maleic acid copolymer: a versatile tool in membrane research

JM Dörr, S Scheidelaar, MC Koorengevel… - European Biophysics …, 2016 - Springer
A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic …

[HTML][HTML] Choosing membrane mimetics for NMR structural studies of transmembrane proteins

DE Warschawski, AA Arnold, M Beaugrand… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

Amphipols, nanodiscs, and fluorinated surfactants: three nonconventional approaches to studying membrane proteins in aqueous solutions

JL Popot - Annual review of biochemistry, 2010 - annualreviews.org
Membrane proteins (MPs) are usually handled in aqueous solutions as protein/detergent
complexes. Detergents, however, tend to be inactivating. This situation has prompted the …

Dual-targeted nanodiscs revealing the cross-talk between osteogenic differentiation of mesenchymal stem cells and macrophages

L Chen, C Yu, W Xu, Y **ong, P Cheng, Z Lin… - ACS …, 2023 - ACS Publications
Ongoing research has highlighted the significance of the cross-play of macrophages and
mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) has been …

[HTML][HTML] Membrane protein synthesis in cell-free systems: From bio-mimetic systems to bio-membranes

R Sachse, SK Dondapati, SF Fenz, T Schmidt, S Kubick - FEBS letters, 2014 - Elsevier
When taking up the gauntlet of studying membrane protein functionality, scientists are
provided with a plethora of advantages, which can be exploited for the synthesis of these …

Probing nanoliposomes using single particle analytical techniques: Effect of excipients, solvents, phase transition and zeta potential

M Danaei, M Kalantari, M Raji, HS Fekri, R Saber… - Heliyon, 2018 - cell.com
There has been a steady increase in the interest towards employing nanoliposomes as
colloidal drug delivery systems, particularly in the last few years. Their biocompatibility …

One-step construction of circularized nanodiscs using SpyCatcher-SpyTag

S Zhang, Q Ren, SJ Novick, TS Strutzenberg… - Nature …, 2021 - nature.com
Circularized nandiscs (cNDs) exhibit superb monodispersity and have the potential to
transform functional and structural studies of membrane proteins. In particular, cNDs can …

The nanodisc: a novel tool for membrane protein studies

J Borch, T Hamann - 2009 - degruyter.com
A major challenge in the research on membrane-anchored and integral membrane protein
complexes is to obtain these in a functionally active, water-soluble, and monodisperse form …

Nanotherapeutic heterogeneity: sources, effects, and solutions

J Morla‐Folch, A Ranzenigo, ZA Fayad, AJP Teunissen - Small, 2024 - Wiley Online Library
Nanomaterials have revolutionized medicine by enabling control over drugs'
pharmacokinetics, biodistribution, and biocompatibility. However, most nanotherapeutic …