Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

[HTML][HTML] MicroRNAs in heart and circulation during physical exercise

L Wang, Y Lv, G Li, J **ao - Journal of sport and health science, 2018 - Elsevier
Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are
a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of …

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

M Bekhite, A González-Delgado, S Hübner… - Free Radical Biology …, 2021 - Elsevier
Oversupply of fatty acids (FAs) to cardiomyocytes (CMs) is associated with increased
ceramide content and elevated the risk of lipotoxic cardiomyopathy. Here we investigate the …

Neuregulin-1/ErbB4 signaling regulates visual cortical plasticity

Y Sun, T Ikrar, MF Davis, N Gong, X Zheng, ZD Luo… - Neuron, 2016 - cell.com
Experience alters cortical networks through neural plasticity mechanisms. During a
developmental critical period, the most dramatic consequence of occluding vision through …

Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering

AC Volz, B Huber, PJ Kluger - Differentiation, 2016 - Elsevier
The development of in vitro adipose tissue constructs is highly desired to cope with the
increased demand for substitutes to replace damaged soft tissue after high graded burns …

Brain-derived neurotrophic factor increases vascular endothelial growth factor expression and enhances angiogenesis in human chondrosarcoma cells

CY Lin, SY Hung, HT Chen, HK Tsou, YC Fong… - Biochemical …, 2014 - Elsevier
Chondrosarcomas are a type of primary malignant bone cancer, with a potent capacity for
local invasion and distant metastasis. Brain-derived neurotrophic factor (BDNF) is commonly …

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease

A Ghigo, M Li - Frontiers in pharmacology, 2015 - frontiersin.org
Class I phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases activated by cell
membrane receptors, either receptor tyrosine kinases (RTKs) or G protein–coupled …

Generation of human vascularized and chambered cardiac organoids for cardiac disease modelling and drug evaluation

J Yang, W Lei, Y **ao, S Tan, J Yang, Y Lin… - Cell …, 2024 - Wiley Online Library
Human induced pluripotent stem cell (hiPSC)‐derived cardiac organoids (COs) have shown
great potential in modelling human heart development and cardiovascular diseases, a …

CD133+ cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma

K Liu, M Hao, Y Ouyang, J Zheng, D Chen - Scientific reports, 2017 - nature.com
The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma
(HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a dramatic …

Hypoxia, leptin, and vascular endothelial growth factor stimulate vascular endothelial cell differentiation of human adipose tissue-derived stem cells

MM Bekhite, A Finkensieper, J Rebhan… - Stem cells and …, 2014 - liebertpub.com
The plasticity of human adipose tissue-derived stem cells (hASCs) is promising, but
differentiation in vitro toward endothelial cells is poorly understood. Flow cytometry …