Gut feelings: the emerging biology of gut–brain communication
EA Mayer - Nature reviews neuroscience, 2011 - nature.com
The concept that the gut and the brain are closely connected, and that this interaction plays
an important part not only in gastrointestinal function but also in certain feeling states and in …
an important part not only in gastrointestinal function but also in certain feeling states and in …
The enteric nervous system and gastrointestinal innervation: integrated local and central control
The digestive system is innervated through its connections with the central nervous system
(CNS) and by the enteric nervous system (ENS) within the wall of the gastrointestinal tract …
(CNS) and by the enteric nervous system (ENS) within the wall of the gastrointestinal tract …
[HTML][HTML] Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Dietary, microbial, and inflammatory factors modulate the gut-brain axis and influence
physiological processes ranging from metabolism to cognition. The gut epithelium is a …
physiological processes ranging from metabolism to cognition. The gut epithelium is a …
Local immune response to food antigens drives meal-induced abdominal pain
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …
to decreased quality of life, substantial morbidity and high medical costs. Although the …
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …
Gut enterochromaffin cells drive visceral pain and anxiety
Gastrointestinal (GI) discomfort is a hallmark of most gut disorders and represents an
important component of chronic visceral pain. For the growing population afflicted by irritable …
important component of chronic visceral pain. For the growing population afflicted by irritable …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Gut feelings: mechanosensing in the gastrointestinal tract
A Mercado-Perez, A Beyder - Nature Reviews Gastroenterology & …, 2022 - nature.com
The primary function of the gut is to procure nutrients. Synchronized mechanical activities
underlie nearly all its endeavours. Coordination of mechanical activities depends on …
underlie nearly all its endeavours. Coordination of mechanical activities depends on …
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
S Huang, CGK Ziegler, J Austin, N Mannoun… - Cell, 2021 - cell.com
Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …
Histamine receptor H1–mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome
MM Wouters, D Balemans, S Van Wanrooy, J Dooley… - Gastroenterology, 2016 - Elsevier
Background & Aims Histamine sensitizes the nociceptor transient reporter potential channel
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …