Introduction Long-term control of HIV-1 infection can potentially be achieved using
autologous stem cell transplants with gene-modified cells. Non-coding RNAs represent a …

Dysregulation of RNA splicing causes many diseases and disorders. Several therapeutic
approaches have been developed to correct aberrant alternative splicing events for the …

The human transcriptome is highly dynamic, with each cell type, tissue, and organ system
expressing an ensemble of transcript isoforms that give rise to considerable diversity. Apart …

Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …

Splicing of pre-mRNA is a crucial regulatory stage in the pathway of gene expression. The
majority of human genes that encode proteins undergo alternative pre-mRNA splicing and …

The human U1 snRNA is encoded by a multigene family consisting of transcribed variants
and defective pseudogenes. Many variant U1 (vU1) snRNAs have been demonstrated to not …

U1 interference (U1i) RNAs can be designed to correct splicing defects and target
pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance …

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Small RNA therapies targeting post-integration steps in the HIV-1 replication cycle are
among the top candidates for gene therapy and have the potential to be used as drug …

À ce jour, la seule intervention qui a pu guérir l'infection par le VIH a été la greffe de moelle
osseuse de donneurs résistants au VIH à des receveurs infectés par le VIH. Cette approche …