DNA minor groove binders constitute an important class of derivatives in anticancer therapy.
Some of these compounds form noncovalent complexes with DNA (eg, distamycin A …

With the incidence of slee** sickness in decline and genuine progress being made
towards the WHO goal of eliminating slee** sickness as a major public health concern …

Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic
parasites that cause diseases such as slee** sickness and leishmania and adversely …

Parasitic protozoa comprise diverse aetiological agents responsible for important diseases
in humans and animals including slee** sickness, Chagas disease, leishmaniasis …

In moving towards the simulation of larger nucleic acid assemblies over longer timescales
that include more accurate representations of the environment, we are nearing the end of an …

Fluorescence microscopy of trypanosomes from drug treated mice shows that biologically
active heterocyclic diamidines that target the DNA minor groove bind rapidly and specifically …

Targeting the minor groove of DNA through binding to a small molecule has long been
considered an important molecular-recognition strategy in biology. A wide range of synthetic …

Statistical analysis of structures from the PBD has been used to examine the role that the
aromatic amino acids play in protein–nucleic acid recognition. In protein–DNA complexes …

High-resolution crystal structures of the DNA duplex sequence d (CGCGAATTCGCG) 2
complexed with three minor-groove ligands are reported. A highly conserved cluster of 11 …

Parasitic infections are widespread in develo** countries and frequently associated with
immunocompromised patients in developed countries. Consequently, such infections are …