[HTML][HTML] SARS-CoV-2 Omicron variant: recent progress and future perspectives

Y Fan, X Li, L Zhang, S Wan, L Zhang… - Signal transduction and …, 2022 - nature.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been
a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of …

Nanotechnology-based strategies against SARS-CoV-2 variants

X Huang, E Kon, X Han, X Zhang, N Kong… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …

Antibody escape of SARS-CoV-2 Omicron BA. 4 and BA. 5 from vaccine and BA. 1 serum

A Tuekprakhon, R Nutalai, A Dijokaite-Guraliuc… - Cell, 2022 - cell.com
The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread
rapidly to become globally dominant and has split into a number of sublineages. BA. 1 …

Potent cross-reactive antibodies following Omicron breakthrough in vaccinees

R Nutalai, D Zhou, A Tuekprakhon, HM Ginn, P Supasa… - Cell, 2022 - cell.com
Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we
compare neutralization of Omicron BA. 1, BA. 1.1, and BA. 2. BA. 2 RBD has slightly higher …

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

N Iwata-Yoshikawa, M Kakizaki, N Shiwa-Sudo… - Nature …, 2022 - nature.com
In cultured cells, SARS-CoV-2 infects cells via multiple pathways using different host
proteases. Recent studies have shown that the furin and TMPRSS2 (furin/TMPRSS2) …

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans

Z Wang, P Zhou, F Muecksch, A Cho… - Journal of Experimental …, 2022 - rupress.org
Individuals who receive a third mRNA vaccine dose show enhanced protection against
severe COVID-19, but little is known about the impact of breakthrough infections on memory …

Clinical severity of SARS-CoV-2 omicron variant compared with delta among hospitalized COVID-19 patients in Belgium during autumn and winter season 2021 …

N Van Goethem, PYJ Chung, M Meurisse… - Viruses, 2022 - mdpi.com
This retrospective multi-center matched cohort study assessed the risk for severe COVID-19
(combination of severity indicators), intensive care unit (ICU) admission, and in-hospital …

OMICRON: Virology, immunopathogenesis, and laboratory diagnosis

M Bazargan, R Elahi… - The Journal of Gene …, 2022 - Wiley Online Library
Since its emersion, coronavirus disease 2019 (COVID‐19) has been a significant global
dilemma. Several mutations in the severe acute respiratory virus (SARS‐Co‐2) genome has …

Maternal and perinatal outcomes following pre-Delta, Delta, and Omicron SARS-CoV-2 variants infection among unvaccinated pregnant women in France and …

G Favre, E Maisonneuve, L Pomar, C Daire… - The Lancet Regional …, 2023 - thelancet.com
Background SARS-CoV-2 positive pregnant women are at higher risk of adverse outcomes,
but little evidence is available on how variants impact that risk. We aim to evaluate maternal …

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

CM Lieber, RM Cox, J Sourimant, JD Wolf… - Nature …, 2022 - nature.com
SARS-CoV-2 variants of concern (VOC) have triggered infection waves. Oral antivirals such
as molnupiravir promise to improve disease management, but efficacy against VOC delta …