Diapause is a physiological adaptation to conditions that are unfavorable for growth or
reproduction. During diapause, animals become long-lived, stress-resistant …

Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly
conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is …

Residual feed intake (RFI) is an important measure of feed efficiency for agricultural animals.
Factors associated with cattle RFI include physiology, dietary factors, and the environment …

Gene variant discovery is becoming routine, but it remains difficult to usefully interpret the
functional consequence or disease relevance of most variants. To fill this interpretation gap …

The SH2 containing protein tyrosine phosphatase 2 (SHP2) plays essential roles in
fundamental signaling pathways, conferring on it versatile physiological functions during …

Tissue growth is controlled by various signaling pathways, such as the insulin/IGF-signaling
(IIS) pathway. Although IIS activation is regulated by a complex regulatory network, the …

Aging is inevitable, but the lifespan (duration of life) and healthspan (healthy aging) vary
greatly among individuals and across species. Unlocking the secrets behind these …

Protein phosphorylation is an integral component of signal transduction pathways within
eukaryotic cells, and it is regulated by coordinated interactions between protein kinases and …

While evaluating the effect on lifespan of decreased ribosomal protein (Rp) expression in
Drosophila, we discovered a potential function in the same process for the Molybdenum …

Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor
family. Alterations in human ALK signaling have been implicated in multiple malignancies …