Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …
discovery of several promising drug targets and novel therapeutic strategies to address the …
Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …
[LIVRE][B] Endocannabinoids and their pharmacological actions
RG Pertwee - 2015 - Springer
The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …
receptors, of endogenous compounds known as endocannabinoids that can target these …
Cannabinoids and cannabinoid receptors: The story so far
Like most modern molecular biology and natural product chemistry, understanding
cannabinoid pharmacology centers around molecular interactions, in this case, between the …
cannabinoid pharmacology centers around molecular interactions, in this case, between the …
Molecular dynamics: new frontier in personalized medicine
The field of drug discovery has witnessed infinite development over the last decade with the
demand for discovery of novel efficient lead compounds. Although the development of novel …
demand for discovery of novel efficient lead compounds. Although the development of novel …
New insights in cannabinoid receptor structure and signaling
L Ye, Z Cao, W Wang, N Zhou - Current molecular …, 2019 - ingentaconnect.com
Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid
signaling has been considered the therapeutic target for treating pain, addiction, obesity …
signaling has been considered the therapeutic target for treating pain, addiction, obesity …
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief
The direct activation of cannabinoid receptors (CBRs) results in several beneficial effects;
therefore several CBRs ligands have been synthesized and tested in vitro and in vivo …
therefore several CBRs ligands have been synthesized and tested in vitro and in vivo …
Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage
Abstract Pepcan-12 (RVD-hemopressin; RVDPVNFKLLSH) is the major peptide of a family
of endogenous peptide endocannabinoids (pepcans) shown to act as negative allosteric …
of endogenous peptide endocannabinoids (pepcans) shown to act as negative allosteric …
Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis
The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane
receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the …
receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the …
Discovery of novel ligands for TNF-α and TNF receptor-1 through structure-based virtual screening and biological assay
Tumor necrosis factor α (TNF-α) is overexpressed in various diseases, and it has been a
validated therapeutic target for autoimmune diseases. All therapeutics currently used to …
validated therapeutic target for autoimmune diseases. All therapeutics currently used to …