Epigenetics is a discipline that studies heritable changes in gene expression that do not
involve altering the DNA sequence. Over the past decade, researchers have shown that …

The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

The Latin word" facultas" literally means" opportunity." Facultative heterochromatin (fHC)
then designates genomic regions in the nucleus of a eukaryotic cell that have the …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

There is now evidence that developmental influences have lifelong effects on cardiovascular
and metabolic function and that elements of the heritable or familial component of …

There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear
architecture are regulated by RNA signalling. Although the precise molecular mechanisms …

Abstract LINE-1s, or L1s, are highly abundant retrotransposons comprising 17% of the
human genome. Most L1s are retrotransposition defective; nonetheless, there are∼ 100 full …

RNAs are underexploited targets for small molecule drugs or chemical probes of function.
This may be due, in part, to a fundamental lack of understanding of the types of small …

Traditionally it has been widely accepted that our genes together with adult lifestyle factors
determine our risk of develo** non-communicable diseases such as type 2 diabetes …