The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT 1 and AT
2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …

The kidney plays a fundamental role in maintaining body salt and fluid balance and blood
pressure homeostasis through the actions of its proximal and distal tubular segments of …

Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …

The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

We have demonstrated that the angiotensin-converting enzyme (ACE) genotype is
associated with Alzheimer's disease (AD) in the Japanese population (1). To determine why …

Angiotensin II (Ang II) plays a pivotal role in vascular fibrosis, which leads to serious
complications in hypertension and diabetes. However, the underlying signaling mechanisms …