Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

As the most common symptomatic reason to seek medical consultation, pain is a complex
experience that has been classified into different categories and stages. In pain processing …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …

Chronic pain often leads to the development of sleep disturbances. However, the precise
neural circuit mechanisms responsible for sleep disorders in chronic pain have remained …

Central sensitization caused by spinal disinhibition is a key mechanism of mechanical
allodynia in neuropathic pain. However, the molecular mechanisms underlying spinal …

Dysfunction in the mesocortical pathway, connecting the ventral tegmental area (VTA) to the
prefrontal cortex, has been implicated in chronic pain. While extensive research has focused …

Although pain-related excessive fear is known to be a key factor in chronic pain disability,
which involves the anterior cingulate cortex (ACC), little is known about the downstream …

Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory system and is
characterized by abnormal hypersensitivity to stimuli and nociceptive responses to non …

Light has been shown to relieve pain, but the underlying neural mechanisms remain
unknown. Here, we show that low-intensity (200 lux) green light treatment exerts …