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DNA methylation at the crossroads of gene and environment interactions
PP Law, ML Holland - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …
for normal development in mammals. It has been observed that the developmental …
Transmission of trained immunity and heterologous resistance to infections across generations
N Katzmarski, J Domínguez-Andrés, B Cirovic… - Nature …, 2021 - nature.com
Intergenerational inheritance of immune traits linked to epigenetic modifications has been
demonstrated in plants and invertebrates. Here we provide evidence for transmission of …
demonstrated in plants and invertebrates. Here we provide evidence for transmission of …
A guide to designing germline-dependent epigenetic inheritance experiments in mammals
Recent work has demonstrated that environmental factors experienced by parents can affect
their offspring across multiple generations, and that such transgenerational transmission can …
their offspring across multiple generations, and that such transgenerational transmission can …
Identification, characterization, and heritability of murine metastable epialleles: implications for non-genetic inheritance
A Kazachenka, TM Bertozzi, MK Sjoberg-Herrera… - Cell, 2018 - cell.com
Generally repressed by epigenetic mechanisms, retrotransposons represent around 40% of
the murine genome. At the Agouti viable yellow (A vy) locus, an endogenous retrovirus …
the murine genome. At the Agouti viable yellow (A vy) locus, an endogenous retrovirus …
Epigenetic inheritance and its role in evolutionary biology: re-evaluation and new perspectives
W Burggren - Biology, 2016 - mdpi.com
Epigenetics increasingly occupies a pivotal position in our understanding of inheritance,
natural selection and, perhaps, even evolution. A survey of the PubMed database, however …
natural selection and, perhaps, even evolution. A survey of the PubMed database, however …
CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory
elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we …
elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we …
Extensive sex differences at the initiation of genetic recombination
K Brick, S Thibault-Sennett, F Smagulova, KWG Lam… - Nature, 2018 - nature.com
Meiotic recombination differs between males and females; however, when and how these
differences are established is unknown. Here we identify extensive sex differences at the …
differences are established is unknown. Here we identify extensive sex differences at the …
Establishment of environmentally sensitive DNA methylation states in the very early human embryo
NJ Kessler, RA Waterland, AM Prentice, MJ Silver - Science advances, 2018 - science.org
The molecular mechanisms responsible for the developmental origins of later disease are
currently unknown. We previously demonstrated that women's periconceptional nutrition …
currently unknown. We previously demonstrated that women's periconceptional nutrition …
[HTML][HTML] Impact of historic migrations and evolutionary processes on human immunity
J Domínguez-Andrés, MG Netea - Trends in Immunology, 2019 - cell.com
The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …
The various populations of modern humans that ventured out of Africa adapted to different …
A survey of inter-individual variation in DNA methylation identifies environmentally responsive co-regulated networks of epigenetic variation in the human genome
While population studies have resulted in detailed maps of genetic variation in humans, to
date there are few robust maps of epigenetic variation. We identified sites containing …
date there are few robust maps of epigenetic variation. We identified sites containing …