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The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
Therapeutic advances of targeting receptor tyrosine kinases in cancer
Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …
significant clinical attention in oncology due to their central role in cancer pathogenesis …
[HTML][HTML] Navigating the ERK1/2 MAPK cascade
The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …
processes including proliferation, cell cycle control, growth, and survival; common across all …
Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
Abstract The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated
pathways in human cancer. Approximately 50% of melanoma patients possess a druggable …
pathways in human cancer. Approximately 50% of melanoma patients possess a druggable …
JNK signaling: regulation and functions based on complex protein-protein partnerships
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
RAF family kinases are RAS-activated switches that initiate signalling through the MAP
kinase cascade to control cellular proliferation, differentiation and survival,–. RAF activity is …
kinase cascade to control cellular proliferation, differentiation and survival,–. RAF activity is …
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction …
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction …
New perspectives for targeting RAF kinase in human cancer
The discovery that a subset of human tumours is dependent on mutationally deregulated
BRAF kinase intensified the development of RAF inhibitors to be used as potential …
BRAF kinase intensified the development of RAF inhibitors to be used as potential …
Regulation of RAF protein kinases in ERK signalling
RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …