[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

S Zhang, H Yang, M Wang, D Mantovani, K Yang… - The Innovation, 2023 - cell.com
Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

Neutrophil extracellular traps in bacterial infections and evasion strategies

AA Baz, H Hao, S Lan, Z Li, S Liu, S Chen… - Frontiers in …, 2024 - frontiersin.org
Neutrophils are innate immune cells that have a vital role in host defense systems.
Neutrophil extracellular traps (NETs) are one of neutrophils' defense mechanisms against …

SOD3 suppresses early cellular immune responses to parasite infection

Q Li, K Lv, N Jiang, T Liu, N Hou, L Yu, Y Yang… - Nature …, 2024 - nature.com
Host immune responses are tightly controlled by various immune factors during infection,
and protozoan parasites also manipulate the immune system to evade surveillance, leading …

Accelerated healing of infected diabetic wounds by a dual-layered adhesive film cored with microsphere-loaded hydrogel composite dressing

B Qin, S Wu, H Dong, S Deng, Y Liu… - … Applied Materials & …, 2023 - ACS Publications
Diabetic wounds, a prevalent chronic disease, are associated with older age. The
hyperglycemic microenvironment in diabetic wounds significantly reduces the immune …

Staphylococcus aureus and Neutrophil Extracellular Traps: The Master Manipulator Meets Its Match in Immunothrombosis

S Meyers, M Crescente, P Verhamme… - … , and Vascular Biology, 2022 - ahajournals.org
Over the past 10 years, neutrophil extracellular traps (NETs) have become widely accepted
as an integral player in immunothrombosis, due to their complex interplay with both …

Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

S Bai, X Wen, B Li, R Hu, J Yang, Q Yu, X Zeng, H Feng… - Cell Reports, 2024 - cell.com
Methicillin-resistant Staphylococcus aureus (MRSA) infection, a major cause of hospital-and
community-acquired pneumonia, still has a high mortality rate. Extracellular vesicles (EVs) …

The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia

C Langouët-Astrié, K Oshima, SA McMurtry, Y Yang… - Cell reports, 2022 - cell.com
Influenza infection is substantially worsened by the onset of secondary pneumonia caused
by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional …

[HTML][HTML] Octanoic acid promotes clearance of antibiotic-tolerant cells and eradicates biofilms of Staphylococcus aureus isolated from recurrent bovine mastitis

WC Lin, KC Hsu, MF You, KH Lee, CH Chi, JY Chen - Biofilm, 2023 - Elsevier
Antibiotic therapy is the primary treatment for bovine mastitis, but the drawbacks of this
strategy include poor cure rate and economic losses from the need to discard milk with …

[HTML][HTML] Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

F Yang, M Suo, H Weli, M Wong, A Junidi, C Cummings… - Cell reports, 2023 - cell.com
The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis.
While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to …