Recent advances in bioactive pyrazoles

ŞG Küçükgüzel, S Şenkardeş - European Journal of Medicinal Chemistry, 2015 - Elsevier
Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …

The synthetic and biological attributes of pyrazole derivatives: A review

J Dwivedi, S Sharma, S Jain… - Mini Reviews in Medicinal …, 2018 - benthamdirect.com
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for
combinatorial as well as medicinal chemistry. This review presents a detailed overview on …

[HTML][HTML] Synthesis and anticonvulsant activity of some 2-pyrazolines derived from chalcones

N Beyhan, B Kocyigit-Kaymakcioglu, S Gümrü… - Arabian Journal of …, 2017 - Elsevier
Abstract Synthesis of chalcones (1, 3-diarylprop-2-en-1-ones) and 2-pyrazoline derivatives
has been an active field of research due to their established pharmacological effects. In this …

Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic …

MF Mohamed, FM Sroor, NS Ibrahim, GS Salem… - Investigational New …, 2021 - Springer
Two novel chemotherapeutic chalcones were synthesized and their structures were
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …

A new insight into the synthesis and biological activities of pyrazole based derivatives

S Mor, M Khatri, R Punia, S Nagoria… - Mini-Reviews in …, 2022 - benthamdirect.com
This review aims to collate literature work reported by researchers (from 1994 to 2021) to
provide an overview of the available methodologies for the synthesis and diverse …

Anticancer Activity of New Bis-(3-(Thiophen-2-yl)-1H-Pyrazol-4-yl)Chalcones: Synthesis, in-Silico, and in-Vitro Studies

FM Sroor, MF Mohamed, GK Abdullah… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A series of bis-chalcones with alkyl linkers incorporating 3-(thiophen-2-yl) pyrazole 5–10
has been prepared by the condensation reaction of two moles of 3-(thiophen-2-yl) pyrazole …

Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo [b, e] azepine-6, 11-dione derivatives containing 1, 3, 4-oxadiazole units

X He, X Li, J Liang, C Cao, S Li, T Zhang… - Bioorganic & medicinal …, 2018 - Elsevier
Rucaparib and PJ34 were used as the structural model for the design of novel 5 H-dibenzo
[b, e] azepine-6, 11-dione derivatives containing 1, 3, 4-oxadiazole units. And target …

an overview of recent developments in coordination chemistry of polypyrazolylmethylamines. Complexes with N-scorpionate ligands created in situ from pyrazole …

A Adach - Journal of Coordination Chemistry, 2017 - Taylor & Francis
This paper reviews the coordination chemistry of polypyrazolylmethylamines as tripodal
tetradentate (LS= N, N, N-tris (3, 5-dimethylpyrazol-1-ylmethyl) amine) and dipodal tridentate …

Methyl-linked pyrazoles: synthetic and medicinal perspective

T Sharma, J Singh, B Singh, R Kataria… - Mini Reviews in …, 2022 - benthamdirect.com
Pyrazoles, an important and well-known class of the azole family, have been found to show
a large number of applications in various fields, especially medicinal chemistry. Pyrazole …

[PDF][PDF] Synthesis, characterization and antibacterial evaluation of some azole derivatives

M Rani, S Sharma, R Chauhan… - Indian Journal of …, 2017 - pdfs.semanticscholar.org
Purpose: Tremendous rise in development of resistance to the antimicrobials has created
alarming situation for researchers and clinicians. Method: In this regard, an attempt has …