Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
Structure-functional activity relationship of β-glucans from the perspective of immunomodulation: a mini-review
β-Glucans are a heterogeneous group of glucose polymers with a common structure
comprising a main chain of β-(1, 3) and/or β-(1, 4)-glucopyranosyl units, along with side …
comprising a main chain of β-(1, 3) and/or β-(1, 4)-glucopyranosyl units, along with side …
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis
Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the
metastatic microenvironment. Here, we explore the implications of reprogramming pre …
metastatic microenvironment. Here, we explore the implications of reprogramming pre …
[HTML][HTML] Polysaccharides regulate Th1/Th2 balance: a new strategy for tumor immunotherapy
Q Shang, X Yu, Q Sun, H Li, C Sun, L Liu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
T helper (Th) cells have received extensive attention owing to their indispensable roles in
anti-tumor immune responses. Th1 and Th2 cells are two key subsets of Th cells that exist in …
anti-tumor immune responses. Th1 and Th2 cells are two key subsets of Th cells that exist in …
Clinical and physiological perspectives of β-glucans: the past, present, and future
β-Glucans are a group of biologically-active fibers or polysaccharides from natural sources
with proven medical significance. β-Glucans are known to have antitumor, anti-inflammatory …
with proven medical significance. β-Glucans are known to have antitumor, anti-inflammatory …
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer
M Liu, Z Tong, C Ding, F Luo, S Wu… - The Journal of …, 2020 - Am Soc Clin Investig
Macrophages have been linked to tumor initiation, progression, metastasis, and treatment
resistance. However, the transcriptional regulation of macrophages driving the protumor …
resistance. However, the transcriptional regulation of macrophages driving the protumor …
Tumor exosomes block dendritic cells maturation to decrease the T cell immune response
Y Ning, K Shen, Q Wu, X Sun, Y Bai, Y **e, J Pan… - Immunology Letters, 2018 - Elsevier
Tumors can induce the generation and accumulation of immunosuppression in a tumor
microenvironment, contributing to the tumor's escape from immunological surveillance …
microenvironment, contributing to the tumor's escape from immunological surveillance …
Immune-modulatory effects of dietary Yeast Beta-1, 3/1, 6-D-glucan
H Stier, V Ebbeskotte, J Gruenwald - Nutrition journal, 2014 - Springer
Beta-glucans are a heterogeneous group of natural polysaccharides mostly investigated for
their immunological effects. Due to the low systemic availability of oral preparations, it has …
their immunological effects. Due to the low systemic availability of oral preparations, it has …
β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties
Y **, P Li, F Wang - Vaccine, 2018 - Elsevier
Abstract β-glucans, a group of polysaccharides exist in many organism species such as
mushrooms, yeasts, oats, barley, seaweed, but not mammalians, have a variety of biological …
mushrooms, yeasts, oats, barley, seaweed, but not mammalians, have a variety of biological …
A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
Switching macrophages from a pro-tumor type to an anti-tumor state is a promising strategy
for cancer immunotherapy. Existing agents, many derived from bacterial components, have …
for cancer immunotherapy. Existing agents, many derived from bacterial components, have …