Background Amyotrophic lateral sclerosis (ALS) is a global disease, which adversely affects
the life quality of patients and significantly increases the burden of families and society. We …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Therapy of motoneuron diseases entered a new phase with the use of intrathecal antisense
oligonucleotide therapies treating patients with specific gene mutations predominantly in the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known
cure. Approximately 90% of ALS cases are sporadic, although multiple genetic risk factors …

An expansion of the GGGGCC hexanucleotide in the non-coding region of C9orf72
represents the most common cause of familial amyotrophic lateral sclerosis. The objective …

Amyotrophic lateral sclerosis and frontotemporal dementia are two progressive, adult onset
neurodegenerative diseases, caused by the cell death of motor neurons in the motor cortex …

Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

Amyotrophic lateral sclerosis is a rare and fatal neurodegenerative disease characterised by
progressive deterioration of upper and lower motor neurons that eventually culminates in …

Growing evidence supports significant involvement of immune dysfunction in the etiology of
neurodegenerative diseases, several of which also display prominent sex differences across …