Time is brain: the stroke theory of relativity

CR Gomez - Journal of Stroke and Cerebrovascular Diseases, 2018 - Elsevier
Background Since the introduction of the philosophical tenet “Time is Brain!,” multiple lines
of research have demonstrated that other factors contribute to the degree of ischemic injury …

Infarct progression in the early and late phases of acute ischemic stroke

H Saber, DS Liebeskind - Neurology, 2021 - neurology.org
Purpose of Review To explore factors associated with infarct progression in the early and
late phase of acute ischemic stroke in patients undergoing endovascular therapy. Recent …

Association of collateral status and ischemic core growth in patients with acute ischemic stroke

L Lin, J Yang, C Chen, H Tian, A Bivard, NJ Spratt… - Neurology, 2021 - neurology.org
Objective To test the hypothesis that patients with acute ischemic stroke with poorer
collaterals would have faster ischemic core growth, we included 2 cohorts in the study …

High variability in neuronal loss: time is brain, requantified

SM Desai, M Rocha, TG Jovin, AP Jadhav - Stroke, 2019 - ahajournals.org
Background and Purpose—In the setting of acute ischemic stroke because of large-vessel
occlusion (LVO) there is progressive loss of brain tissue which occurs in a time-dependent …

Factors associated with fast early infarct growth in patients with acute ischemic stroke with a large vessel occlusion

P Seners, N Yuen, JM Olivot, M Mlynash, JJ Heit… - Neurology, 2023 - neurology.org
Background and Objectives The optimal methods for predicting early infarct growth rate
(EIGR) in acute ischemic stroke with a large vessel occlusion (LVO) have not been …

Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace

S Jung, R Wiest, J Gralla, R McKinley, HP Mattle… - Swiss medical …, 2017 - smw.ch
Blood supply to the brain is secured by an extensive collateral circulation system, which can
be divided into primary routes, ie, the Circle of Willis, and secondary routes, eg, collaterals …

Clinical and imaging parameters associated with hyperacute infarction growth in large vessel occlusion stroke

D Puhr-Westerheide, S Tiedt, LT Rotkopf, M Herzberg… - Stroke, 2019 - ahajournals.org
Background and Purpose—Large vessel occlusion stroke leads to highly variable
hyperacute infarction growth. Our aim was to identify clinical and imaging parameters …

Characterizing fast and slow progressors in anterior circulation large vessel occlusion strokes

MH Mohammaden, DC Haussen… - Interventional …, 2023 - journals.sagepub.com
Background and Purpose Infarct growth rate (IGR) in acute ischemic stroke is highly
variable. We sought to evaluate impact of symptom-reperfusion time on outcomes in patients …

EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke

B Okyere, WA Mills, X Wang, M Chen, J Chen… - The Journal of Clinical …, 2020 - jci.org
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood
flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is …

Systematic evaluation of computed tomography angiography collateral scores for estimation of long-term outcome after mechanical thrombectomy in acute ischaemic …

D Weiss, B Kraus, C Rubbert… - The Neuroradiology …, 2019 - journals.sagepub.com
Purpose This study compares computed tomography angiography-based collateral scoring
systems in regard to their inter-rater reliability and potential to predict functional outcome …