Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
The origins of COVID‐19 pandemic: A brief overview
YJ Hao, YL Wang, MY Wang, L Zhou… - Transboundary and …, 2022 - Wiley Online Library
The novel coronavirus disease (COVID‐19) outbreak that emerged at the end of 2019 has
now swept the world for more than 2 years, causing immeasurable damage to the lives and …
now swept the world for more than 2 years, causing immeasurable damage to the lives and …
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2
SARS-CoV-2 Omicron rapidly outcompeted other variants and currently dominates the
COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be …
COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be …
[HTML][HTML] An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines
Spillover of sarbecoviruses from animals to humans has resulted in outbreaks of severe
acute respiratory syndrome SARS-CoVs and the ongoing COVID-19 pandemic. Efforts to …
acute respiratory syndrome SARS-CoVs and the ongoing COVID-19 pandemic. Efforts to …
Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness
JY Si, YM Chen, YH Sun, MX Gu, ML Huang… - Nature …, 2024 - nature.com
Our comprehensive understanding of the multi-species ACE2 adaptiveness of
sarbecoviruses remains elusive, particularly for those with various receptor binding motif …
sarbecoviruses remains elusive, particularly for those with various receptor binding motif …
Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist
Among the novel mutations distinguishing SARS-CoV-2 from similar coronaviruses is a
K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within …
K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within …
Chronic shedding of a SARS-CoV-2 Alpha variant in wastewater
MJ Conway, H Yang, LA Revord, MP Novay, RJ Lee… - BMC genomics, 2024 - Springer
Abstract Background Central Michigan University (CMU) participated in a state-wide SARS-
CoV-2 wastewater monitoring program since 2021. Wastewater samples were collected …
CoV-2 wastewater monitoring program since 2021. Wastewater samples were collected …
SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and …
The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-
Asp tripeptide named RGD motif, which has also been identified in extracellular matrix …
Asp tripeptide named RGD motif, which has also been identified in extracellular matrix …
In vitro high-content tissue models to address precision medicine challenges
The field of precision medicine allows for tailor-made treatments specific to a patient and
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
[HTML][HTML] Binding affinity between coronavirus spike protein and human ACE2 receptor
MHH Shum, Y Lee, L Tam, H **a, OLW Chung… - Computational and …, 2024 - Elsevier
Coronaviruses (CoVs) pose a major risk to global public health due to their ability to infect
diverse animal species and potential for emergence in humans. The CoV spike protein …
diverse animal species and potential for emergence in humans. The CoV spike protein …