Variant calling and benchmarking in an era of complete human genome sequences
Genetic variant calling from DNA sequencing has enabled understanding of germline
variation in hundreds of thousands of humans. Sequencing technologies and variant-calling …
variation in hundreds of thousands of humans. Sequencing technologies and variant-calling …
Gmx: Instruction set extensions for fast, scalable, and efficient genome sequence alignment
Sequence alignment remains a fundamental problem in computer science with practical
applications ranging from pattern matching to computational biology. The ever-increasing …
applications ranging from pattern matching to computational biology. The ever-increasing …
BLEND: a fast, memory-efficient and accurate mechanism to find fuzzy seed matches in genome analysis
Generating the hash values of short subsequences, called seeds, enables quickly
identifying similarities between genomic sequences by matching seeds with a single lookup …
identifying similarities between genomic sequences by matching seeds with a single lookup …
Genpip: In-memory acceleration of genome analysis via tight integration of basecalling and read map**
Nanopore sequencing is a widely-used high-throughput genome sequencing technology
that can sequence long fragments of a genome into raw electrical signals at low cost …
that can sequence long fragments of a genome into raw electrical signals at low cost …
[PDF][PDF] Scrooge: a fast and memory-frugal genomic sequence aligner for CPUs, GPUs, and ASICs
Motivation Pairwise sequence alignment is a very time-consuming step in common
bioinformatics pipelines. Speeding up this step requires heuristics, efficient implementations …
bioinformatics pipelines. Speeding up this step requires heuristics, efficient implementations …
[HTML][HTML] Advances in Whole Genome Sequencing: Methods, Tools, and Applications in Population Genomics
Y Lu, M Li, Z Gao, H Ma, Y Chong, J Hong… - International Journal of …, 2025 - mdpi.com
With the rapid advancement of high-throughput sequencing technologies, whole genome
sequencing (WGS) has emerged as a crucial tool for studying genetic variation and …
sequencing (WGS) has emerged as a crucial tool for studying genetic variation and …
SPARTA: spatial acceleration for efficient and scalable horizontal diffusion weather stencil computation
Fast and accurate climate simulations and weather predictions are critical for understanding
and preparing for the impact of climate change. Real-world climate and weather simulations …
and preparing for the impact of climate change. Real-world climate and weather simulations …
Accelerating genome analysis via algorithm-architecture co-design
High-throughput sequencing (HTS) technologies have revolutionized the field of genomics,
enabling rapid and cost-effective genome analysis for various applications. However, the …
enabling rapid and cost-effective genome analysis for various applications. However, the …
SieveMem: a computation-in-memory architecture for fast and accurate pre-alignment
The high execution time of DNA sequence alignment negatively affects many genomic
studies that rely on sequence alignment results. Pre-alignment filtering was introduced as a …
studies that rely on sequence alignment results. Pre-alignment filtering was introduced as a …
MegIS: High-Performance, Energy-Efficient, and Low-Cost Metagenomic Analysis with In-Storage Processing
Metagenomics, the study of the genome sequences of diverse organisms in a common
environment, has led to significant advances in many fields. Since the species present in a …
environment, has led to significant advances in many fields. Since the species present in a …