The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …

Plasma biomarkers for Alzheimer's disease-related pathologies have undergone rapid
developments during the past few years, and there are now well-validated blood tests for …

Abstract Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid
(CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly …

In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …

Importance TheAPOEε2 andAPOEε4 alleles are the strongest protective and risk-increasing,
respectively, genetic variants for late-onset Alzheimer disease (AD). However, the …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …

There is ample pathological and biological evidence for endo-lysosomal dysfunction in
Alzheimer's disease (AD) and emerging genetic studies repeatedly implicate endo …