MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
MicroRNA-155: a master regulator of inflammation
MicroRNAs (miRNAs) are naturally occurring, highly conserved families of transcripts (∼ 22
nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily …
nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily …
[HTML][HTML] Anoikis molecular pathways and its role in cancer progression
Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix,
behaving as a critical mechanism in preventing adherent-independent cell growth and …
behaving as a critical mechanism in preventing adherent-independent cell growth and …
Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …
MicroRNAs in development and disease
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising …
Background: Chemoresistance is a significant clinical problem in pancreatic cancer (PC)
and underlying molecular mechanisms still remain to be completely understood. Here we …
and underlying molecular mechanisms still remain to be completely understood. Here we …
MicroRNA-155 controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinoma
M Mikamori, D Yamada, H Eguchi, S Hasegawa… - Scientific reports, 2017 - nature.com
The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal
adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term …
adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term …
MicroRNA-10a binds the 5′ UTR of ribosomal protein mRNAs and enhances their translation
MicroRNAs (miRNAs) are small RNAs that function as posttranscriptional regulators of gene
expression. miRNAs affect a variety of signaling pathways, and impaired miRNA regulation …
expression. miRNAs affect a variety of signaling pathways, and impaired miRNA regulation …
MicroRNAs in NF-κB signaling
X Ma, LE Becker Buscaglia… - Journal of molecular cell …, 2011 - academic.oup.com
Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …
MicroRNA function in cancer: oncogene or a tumor suppressor?
SK Shenouda, SK Alahari - Cancer and metastasis reviews, 2009 - Springer
MicroRNAs (miRNAs) are small noncoding, double-stranded RNA molecules that can
mediate the expression of target genes with complementary sequences. About 5,300 human …
mediate the expression of target genes with complementary sequences. About 5,300 human …